Insights into Lewy body disease from rare neurometabolic disorders
نویسندگان
چکیده
منابع مشابه
Rare genetic variants support mitochondrial dysfunction in Lewy body disorders.
Parkinson disease (PD) and other Lewy body disorders are common neurodegenerative conditions manifesting with progressive motor and nonmotor symptoms. Although their pathogenesis remains to be fully elucidated, a number of genetic findings have helped better understand the molecular mechanisms involved. Mutations in genes causing PD that are inherited in a Mendelian fashion as well as genetic v...
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1 Department of Psychiatry and Psychotherapy, University Hospital of Tuebingen, Calwer Str. 14, 72076 Tuebingen, Germany Alzheimer Neurobiology Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, 141 86 Stockholm, Sweden German Center for Neurodegenerative Diseases (DZNE), Otfried Müller-Strasse 27, 72076 Tuebingen, Germany 4 Section for Dementia Research, Hert...
متن کاملCortical Lewy body disease.
C ortical Lewy body disease is a pathological observation rather than a distinct clinicopathological entity. Cortical Lewy bodies (CLB) are typically found in Parkinson’s disease and dementia with Lewy bodies (DLB), although they may also occur in other neurological disorders. Unlike their brain stem counterparts, CLB are less distinctive and are poorly visualised using conventional histochemic...
متن کامل[Diffuse Lewy body disease].
Diffuse Lewy body disease (DLBD) has been studied from various viewpoints and, although clinical diagnostic criteria for DLBD have been proposed, diagnosis remains difficult. DLBD has been reported to be the second most common form of dementia in the aged, following Alzheimer-type dementia. It has, however, been clinically under-diagnosed. Therefore, the search for diagnostic markers for DLBD m...
متن کاملFrom Lewy body disease to Alzheimer's disease: hypothesis and evidence.
The mechanisms underlying Alzheimer's disease and Lewy body disease have long been a controversial subject among neurologists and neuropathologists. Here, we hypothesize that three most common histopathological structures, Lewy body (LB), neurofibrillary tangle (NFT) and neuritic senile plaque (NP) found in neurodegenerative diseases are different stages of the same lesion. Lewy body disease (L...
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ژورنال
عنوان ژورنال: Journal of Neural Transmission
سال: 2021
ISSN: 0300-9564,1435-1463
DOI: 10.1007/s00702-021-02355-7